In colon cancer (large intestine cancer ), approximately 15% of patients can develop peritoneum cancer. Often, it is a combination of seeding to the peritoneum and seeding to the liver and / or other organs. In 3% of patients, limited seeding to the peritoneum. For this group of patients that HIPEC may be indicated (see below).
In ovarian cancer, about 75% of patients develop peritoneal cancer. In 50% of patients, limited seeding to the peritoneum. For this group of patients that HIPEC may be indicated (see below).
A pseudomyxome is a rare form of peritoneal cancer. It is caused by a small tumor, benign in itself, at the base of the appendix, which compresses and prevents the passage of mucus. The mucus accumulates in the appendix ruptures with mucus and implantation of tumor cells in the cavity of the abdomen. Tumor cells continue to produce mucus, which causes bloating of the belly, a joining of the intestines and an occlusion (see above). HIPEC is a treatment of choice for this tumor that grows slowly.
Mesothelioma is a rare form of peritoneal cancer which has its roots in the cells of the peritoneum and is often caused by asbestos. In a first variant, there is a lot of ascites (fluid in the abdomen) and tumor homes are very fine and rather mild. In a second variant, there is little ascites tumor homes but are thicker and less benign. The HIPEC may be indicated especially in the first variant.
stomach Cancer is a frequent seeding to the peritoneum. In Japan, HIPEC is applied as a preventative measure for advanced gastric cancer, with apparently good results. Stomach cancer in Japan and stomach cancer in the West are not strictly comparable. There is still no reliable scientific data on the potential benefit of HIPEC in stomach cancer in the West.
Finally, peritoneal cancer may be a complication of many tumors within or outside the abdomen such as cancer of the pancreas, biliary tract cancer, sarcoma (cancer of connective tissue) and cancer breast. Currently there is no scientific data that support the application of HIPEC for these indications.
